What is TRD?
Treatment Resistant Depression (TRD)

For many people coping with Major Depressive Disorder (MDD) antidepressants have proven to provide adequate symptom relief enabling them to resume the life they once enjoyed. However, some patients experience a form of MDD known as TRD when standard medications provide little to no relief.

As many as two-thirds of depressed patients aren’t helped by the first antidepressant they try. Approximately one-third of adults with major depression are considered “treatment resistant”, continuing to battle symptoms such as persistent feelings of sadness, sleep disturbances, low energy, and thoughts of death or suicide.¹,²

If you think this sounds familiar you should discuss and answer the following questions with your doctor:

  • Has your treatment failed to make you feel better?
  • Has your treatment helped a bit, but you still don’t feel like your old self?
  • Have the side effects of your medication been difficult to deal with?
  • Is TMS a treatment option for me?

¹Ionescu, D. F., Rosenbaum, J. F., & Alpert, J. E. (2015). Pharmacological approaches to the challenge of treatment-resistant depression. Dialogues in clinical neuroscience, 17(2), 111–126.

²Rush, A. J., Trivedi, M. H., Wisniewski, S. R., Nierenberg, A. A., Stewart, J. W., Warden, D., Niederehe, G., Thase, M. E., Lavori, P. W., Lebowitz, B. D., McGrath, P. J., Rosenbaum, J. F., Sackeim, H. A., Kupfer, D. J., Luther, J., & Fava, M. (2006). Acute and longer-term outcomes in depressed outpatients requiring one or several treatment steps: a STAR*D report. The American journal of psychiatry, 163(11), 1905–1917. https://doi.org/10.1176/ajp.2006.163.11.1905